Search Results for: colorectal cancer
Targeting cancer stemness: A new approach to target tumour metastasis in colorectal cancer
At COARE Holdings in the US, Dr Courtney W Houchen and Edwin Bannerman-Menson examine innovative ways to target and treat metastatic colorectal cancer (mCRC). Their research focuses on the ‘stemness’ […]
Improving the effectiveness of an anticancer fluoropyrimidine by molecular hybridisation
Capecitabine (Cape) – a fluoropyrimidine used primarily in the treatment of breast and colorectal cancer – disrupts the synthesis of DNA in cancer cells following its conversion to 5-fluorouracil (FU). […]
Probing Cancer: Immunotherapy and Molecular Imaging
The Singapore-based Cancer ImmunoTherapy Imaging (CITI) programme is a Singapore-wide collaborative research group, comprising 12 research institutes. CITI’s efforts are focused on the discovery and application of peptide-based imaging probes, […]
A new weapon to boost cancer immunotherapy
In recent years, immunooncology has paved new avenues for effective treatment across cancer types. In addition to cytotoxic chemotherapy, we can now harness the power of the human immune response […]
Discovering the metastasome A new way to understand cancer metastasis
Cancer treatment is improving all the time, but one area where progress has been slower is in the treatment of metastases, the secondary growths that break away from the initial […]
Whole-body MRI more efficient than multiple scans at assessing spread of cancer
For most patients, a cancer diagnosis means some tough times ahead. Standard assessments to determine the best treatment can be time-consuming, adding to the patient’s stress and anxiety. Professor Stuart […]
Reduced PSA Prostate Cancer Screening: Life-threatening consequences?
In 2012, the United States Preventive Services Task Force issued a grade D recommendation against PSA-based prostate cancer screening. This is because early diagnosis of low-grade cancers can lead to unnecessary […]
The genomics of cancer
Many cancers are associated with changes to our genetic material, DNA. These may be small, single unit substitutions, large rearrangements such as deletions or duplications of a part of the […]
Spiking of urinary biomarker with exercise: A marker of muscle inflammation?
Seeking a sensitive biomarker of inflammation, Emeritus Professor Isao Okayasu of Kiryu University and Kitasato University, Japan and his colleagues have spent over two decades investigating chronic organ inflammation and […]
One cell’s death is a microbe’s DINNR: How intestinal bacteria use our dying cells as fuel
Until now, a great deal has remained unknown about the relationship between programmed cell death and bacterial infections. However, recent work by Dr CJ Anderson and Professor Kodi Ravichandran from […]