Light therapy improves cognitive function after traumatic brain injury

traumatic brain injury is on the rise. The Centers for Disease Control and Prevention estimate an increase of over a million cases were seen when comparing rates of incidence in 2001 with 2010. The impact of a traumatic brain injury can be felt across many aspects of a sufferer’s life. Sufferers are subject to impaired cognitive function alongside reduced mental wellbeing. Anxiety, depression and other psychological symptoms are also found to be widely experienced by survivors of traumatic brain injury.

TREATING A SILENT EPIDEMIC Traumatic brain injuries have been termed a 'silent epidemic' in the US due to their apparent rise in prevalence.These injuries can be categorised according to their seriousness with as many as 85% of reported cases being considered mild traumatic brain injury.The vast majority of sufferers of a mild traumatic brain injury go on to recover completely within three months however, for those whose symptoms persist, they join

Light therapy improves cognitive function after traumatic brain injury
Traumatic brain injuries affect millions of people every year and the longterm symptoms are often unresponsive to current treatments.Dr Greg Hipskind and his team have developed a novel method of light therapy which seeks to improve cognitive function and cerebral blood flow.Results are extremely positive for a study cohort of 12 military Veterans living with the consequences of mild traumatic brain injury.
Health & Medicinehundreds of thousands of fellow sufferers in a 'miserable minority,' often left with little hope of success from currently available treatments.
Traumatic brain injuries can affect individuals from all walks of life, and have differing causes.One group within society who may be at higher likelihood of living with chronic traumatic brain injury symptoms is military personnel.For this study, 12 US military Veterans suffering from chronic traumatic brain injury were invited to participate.

TREATMENT OPTIONS FOR MILD TRAUMATIC BRAIN INJURIES
In cases of severe and moderate acute traumatic brain injury, highly developed techniques such as CT or MRI imaging can be hugely successful in detecting the extent of the injury and helping to determine the most appropriate treatment plan.Unfortunately for sufferers of mild traumatic brain injuries these technologies are often insufficiently sensitive to be able to detect the specific abnormalities found in the brain.The damage found in the brain of a person suffering from chronic mild traumatic brain injury is primarily metabolic in nature and is better detected by metabolic imaging technology found using PET or SPECT (single photon emission computed tomography) imaging.
A novel therapy for mild traumatic brain injury shown to be successful in both human and animal models is photobiomodulation therapy conducted with light-emitting diodes (LEDs).This involves the use of red/NIR light applied directly to the head to treat the brain injury.Research has also shown that near-infrared light transmitted with LEDs is capable of penetrating the human skull.There has been extensive work to define the range of light frequencies which are most effective and also whether light application is more effective if it is constant or pulsed.By drawing conclusions from this vast body of research, Dr Greg Hipskind has devised a method which uses a combination of pulsed red and near infra-red light applied directly to the skull using LEDs to conduct photobiomodulation therapy.
The study cohort consisted of 12 Veterans who had sustained their injuries in a broad range of activities including motor vehicle accidents, sports injuries and exposure to improvised explosive devices.The participants were all male and ranged in age from 31-56 years.All of the men experienced symptoms relating to their injuries and had been injured more than 18 months before the start of the study.It was important for the research team to ensure 18 months had elapsed as this is the window typically allowed for the brain to restore all recoverable function naturally.The research team consisted of a multidisciplinary group including research scientists and medical professionals able to administer treatment.The treatment was offered at one of two medical clinics.

Traumatic brain injuries have been termed
a 'silent epidemic' in the United States due to their apparent rise in prevalence.

Dr Greg Hipskind
Military personnel are particularly at risk from traumatic brain injury.
Although CT imaging is successfully used to detect severe and moderate acute traumatic brain injury, it is not sensitive enough for mild traumatic brain injury.

Detail
Research Objectives

Personal Response
The life changing impact of your research for those treated so far is clear to see.What has been the most impressive example of restored cognitive function you've experienced?
One participant, previously disabled by suicidal ideation and depression, responded so well to light therapy intervention that he was able to be hired and actively participate as an assistant coach for a national collegiate sports team.With continued maintenance therapy he remains successfully employed.Dr Hipskind's research focuses on clinical and functional brain imaging evaluation of patients with neurobehavioral disorders.
Dr Greg Hipskind cerebral blood flow increases.All 12 participants verbally reported substantial reductions in many of their symptoms.
In order to produce such positive results, it is clear the brain is capable of responding to LED light therapy delivered in this format.It is theorised that the treatment causes release of nitric oxide from red blood cells which triggers the vasodilation process as well as triggering the manufacture of anti-inflammatory molecules and neuroprotective factors.

A BRIGHT FUTURE FOR LED TREATMENTS
The opportunity for further work created by this small-scale study is huge.A limitation identified in this study was the lack of resource to adequately explore the effect of treatment on lifestyle and mental wellbeing, for example by monitoring sleep and stress levels.Of course, the identification of limitations in a small-scale study provides ample opportunity for further research.Indeed, the future looks promising for this novel treatment method and the millions of people suffering from traumatic brain injury around the world.cognitive ability was improved by the photobiomodulation treatment.
Cerebral blood flow was quantitatively measured using SPECT technology measuring blood flow in 138 different regions of the brain.The scan was conducted after the neuropsychological tests and required patients to relax in a reclining chair in a semi-darkened room wearing noise cancelling headphones before having a tracer injected through an established IV line.As a decrease in regional cerebral blood flow is commonly associated with traumatic brain injury the researchers in this study chose to investigate whether an increase in regional cerebral blood flow would be seen during treatment.
Following the predetermined course of treatment, all participants displayed improvement in 14 of the 15 neuropsychological assessments with significant improvement on six of 15 neuropsychological tests including memory, concentration and processing speed.The SPECT scan image analysis revealed that eight of the 12 participants demonstrated significant regional Photobiomodulation treatment of brain injuries: light is directly applied to the patient's head.
Bio S. Gregory Hipskind MD PhD is a Behavioural and Nuclear Neurologist who is a nationally recognised expert in the evaluation of traumatic brain injury and carbon monoxide poisoning utilising advanced, quantitative nuclear brain SPECT imaging.He was certified as a Brain Injury Specialist in 2010.He is a published expert in the evaluation of traumatic brain injury using quantitative brain SPECT imaging and its treatment using light therapy and photobiomodulation.He is considered one of the nation's leading forensic experts in advocating for the brain injured patient.Dr Hipskind is President of Brain Injury Consulting, LLC.Funding Funded by the Tug McGraw Foundation Collaborators • Fred Grover MD • Dennis Helffenstein PhD • Thomas Burke PhD • Richard Fort PhD • Marybeth Lehto PhD • Jody Mittiga DNM ANP E: DrGreg@braininjuryconsultingllc.com T: +1-618-213-6773 W: www.braininjuryconsultingllc.com Behind the Research References Hipskind, S.G., Grover Jr, F.L., Fort, T.R., Helffenstein, D., Burke, T.J., Quint, S.A., Bussiere, G., Stone, M. and Hurtado, T., 2018.Pulsed transcranial red/near-infrared light therapy using light-emitting diodes improves cerebral blood flow and cognitive function in veterans with chronic traumatic brain injury: a case series.Photomedicine and Laser Surgery.doi: 10.1089/pho.2018.4489.Hipskind, S.G., Near Infrared Light-Emitting Diodes Do More Than You Think (re: DOI: 10.1089/photob.2018.4603).Photobiomodulation, Photomedicine, and Laser Surgery, 37(2), pp.126-127.doi:10.1089/photob.2019.4620. PHOTOBIOMODULATION