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Biopsy-proven juvenile IgG4 related disease (IgG4RD) in a case with recurrent unilateral peri-orbital swelling

  Immunoglobulin G4 Related Diseases (IgG4-RD) are a newly recognized cohort of systemic fibroinflammatory conditions with raised serum concentrations of IgG4 (Stone et al., 2012). These lesions can occur in several organs with differing pathological manifestations; however, the most common presentations are: Type-1 autoimmune pancreatitis, salivary gland disease, orbital disease and retroperitoneal fibrosis (Moutsopoulos et al., 2017). This is the […]

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Peeping into the oxidative state of germline stem cells

  In simplest terms, respiration is a process by which organisms breathe in oxygen and exhale carbon-dioxide. At the molecular level respiration aids in generation of energy in the form of Adenosine tri-phosphate (ATP) from chemical reactions involving electron transfer through molecular oxygen. These reactions primarily take place in the mitochondria of the cells and during the process derivatives of […]

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How brain activity evolves from fear to anxiety: Implications for today’s mental well-being

  Post-traumatic stress syndrome (PTSD) is predicted to be a long-term outcome from today’s frightening turbulence. Life-threatening fear is traumatic and can have enduring effects on mental health. Yet we still need to understand the brain’s response to fear and how that response changes with recovery or progression to anxiety states like PTSD. While inducing fear in humans for research […]

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A call for reform in pollinator pesticide risk assessment

  Purpose of Risk Assessments Risk assessments have two important functions: (1) To evaluate the likelihood that pollinators might be exposed to pesticides and (2) To determine potential negative impacts on pollinator health. Methods used for such risk assessments should consider all possible routes of exposure, if a pesticide is systemic, how it is applied, its persistence and its toxicity […]

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Reactive slow waves and state-dissociation in sleep underlie several NREM-sleep states and pathological conditions

  Stimuli disturbing non-rapid eye movement sleep (NREM sleep; slow wave sleep) may increase the level of vigilance “arousing” the sleeper. A conventional arousal typically manifests as a fast and low-voltage EEG pattern (desynchronisation). Contrasting this “normal” expectation, EEG slow waves (sleep-like synchronised activity) may also develop in response to arousing stimulation during NREM sleep. These reactive slow waves carry […]

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Stratum corneum: our skin’s protection and major challenge

  How to deceive the skin barrier? The stratum corneum is the uppermost layer of the skin and acts as a barrier to keep out contaminants and to retain moisture. It is composed of the most hydrophobic (water-fearing) lipids in nature. The more relevant are ceramides and cholesterol, forming a truly solid-like lipid structure. The skin permeability barrier function is […]

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Patient involvement in assessing consultation quality

&nbsp Patient enablement can be defined as the extent to which a patient is capable of understanding and coping with his or her health issues. This concept is linked to a number of health outcomes such as self-management of chronic diseases and quality of life. Dr Aelita Skarbaliene from Klaipeda University (Lithuania) together with colleagues from Lund University (Sweden) and […]

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Some recent medical perspectives on the death of King Tutankhamen

  The word “mummy” often conjures up before our mind’s eye the horror movies in which an embalmed body rises up to scare off intruders in a pyramid or a tomb who are in search of treasures or valuables. This, at least, is the plot structure of the 1999 horror-thriller film The Mummy . But it has to be borne […]

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Benchmarking Design: multiplying the impact of technical assistance to MSMEs in design and product development

  Applications of benchmarking in the Province of Buenos Aires In previous work, we surveyed and analysed various applications of benchmarking tools in the public sector through international, national, subnational and local organisations. In the provincial public sphere, different organisations are currently applying the technique of benchmarking for improvement and institutional development. In this sense, the policy applications of benchmarking […]

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‘Intelligent’ lenses reshape to control astigmatism

  In recent years, significant efforts have increasingly been focused on the development of optical lenses with electrically tuneable focal length. They are intended to replace conventional glass-made lenses moved by motors for focussing, in systems that are limited by the complexity, size, weight and response time of this typical approach. Examples include video cameras in a broad diversity of […]

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