Health & Medicine

The PROgress Study: An electronic solution for improving patient consultation visits in routine HIV care

HIV therapy has been a spectacular success over the past 30 years, transforming a disease that was once considered a life sentence into a manageable, chronic condition. With treatments so effective, clinical focus has now changed to looking at ways of improving patients’ quality of life. Understanding each individual’s unique situation is key yet this presents a challenge for care […]

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Health & Medicine

How can diet influence women’s reproductive health?

The majority of clinical trials focus on male participants. Dr Dequina Nicholas, Assistant Professor at the University of California Irvine in the US, argues that there is an urgent need to focus more on women’s health, especially fertility-related complications. She is exploring the impact of what we eat on metabolism, inflammation, and reproduction, expanding the possibility that dietary manipulation can […]

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Health & Medicine

Conjugation chemistry creates affordable childhood vaccines

The immune system provides a formidable defence against pathogens. However, many bacteria possess a protective sugar polymer coat. In children, the immune system does not respond to these polymers unless they are chemically linked to a carrier. This is the basis of conjugate vaccines, a powerful but expensive means to fight diseases like pneumonia, the leading cause of death in […]

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Health & Medicine

The heart of the matter: Clinical electrophysiology and beyond

Arrythmia – abnormal heart rhythm – can be life-limiting and even life-threatening. In this interview, Research Outreach talks to Professor Benjamin J Scherlag of the University of Oklahoma, USA, about his pioneering research into what was the entirely new field of cardiac electrophysiology. We learn about the ‘His bundle’, ganglionated plexi, and how it is possible to treat the heart […]

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Health & Medicine

Novel immunoassays for detection of faecal calprotectin and neutrophil extracellular traps in the gut

Faecal calprotectin (CP) is a valuable biomarker for inflammatory bowel disease (IBD). Nevertheless, commercial assays do not display comparable clinical sensitivities and specificities. Dr Magne Fagerhol at the Oslo University Hospital, Norway, explored the structure of faecal CP to understand the sources of variation and developed new monoclonal antibody mixtures and immunoassay procedures that improved the sensitivity. Moreover, Fagerhol demonstrated […]

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Health & Medicine

Using patient datasets to track COVID-19 prevalence

Obtaining an accurate picture of COVID-19 cases has provided a major challenge throughout the pandemic. Changes in testing methods and skewed selection of higher-risk groups may bias the results. Dr Amy Hou, Dr Genevieve Pang, and Dr Lorrin Pang at the Hawaii State Department of Health, Maui District Health Office, US, propose a novel way to estimate local prevalence of […]

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Health & Medicine

Usher syndrome: Recent advances in our understanding of genes and therapeutics

Usher syndrome is a rare disease that affects the sensory systems of vision, hearing, and balance. Recent advances in scientific technologies reveal the genes involved in Usher syndrome, their varying phenotypic outcomes, and avenues for therapeutic development. Dr Aziz El-Amraoui of the Pasteur Institute in Paris, France, and Dr Gwenaelle Géléoc of Boston Children’s Hospital and Harvard Medical School in […]

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Health & Medicine

Month of birth, ultraviolet radiation exposure, and the development of major mental illnesses

Major mental illnesses (MMIs) are a significant global health burden. Recent data confirms that MMI is associated with an individual’s month of birth (MOB). Levels of ultraviolet radiation (UVR) vary during the calendar year, and over cyclic periods UVR intensity peaks. UVR can cause cellular mutations and affect epigenetic processes, therefore exposure at conception or during early gestation potentially has […]

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Health & Medicine

Making strides in veterinary pathology: A dedicated career

Mast cell tumours and pancreatic diseases are common in dogs but also present to a lesser degree in other veterinary species, including cats and horses. For these and many other diseases of veterinary species, diagnostic methods and criteria were not well characterised and made determination of prognosis difficult. Changing this, with decades of research into the pathology of veterinary diseases, […]

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