Health & Medicine

Predicting treatment resistance in schizophrenia patients

Schizophrenia is a severe and often debilitating mental disorder. While antipsychotic medications aim to alleviate the symptoms, about a third of patients with schizophrenia are treatment-resistant. Dr Olesya Ajnakina, a Research Fellow at King’s College London, combines state-of-the-art methods in statistical analyses, such as machine learning, to develop prediction models aiming to identify patients at risk of developing treatment-resistant schizophrenia, […]

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Health & Medicine

Geovisualization for insights into infectious disease risk

Environmental, social, and economic factors influence infectious disease transmission and resulting risk. Using exploratory data analysis techniques can help uncover previously unknown relationships between these factors, contributing to improved public health efforts. Drs Abhishek Kala, Samuel Atkinson, and Chetan Tiwari from the University of North Texas, USA, use geovisualization to identify the spatial context and factors that are strongly associated […]

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Health & Medicine

Machine learning paves the way to advances in genome sequencing

Genome sequencing platforms are transforming the field of genetic disease research as they offer a closer look at human genes and DNA for clinical diagnostics. Based on machine learning methods, DeepSimulator provides simulated datasets to train and test sequencing analytical tools while WaveNano has innovated the process of translating a raw signal sequence into a DNA read. Dr Xin Gao […]

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Health & Medicine

Improving the management of heart failure with telemedicine

Guaranteeing timely and good quality healthcare for all can be challenging. In countries like Denmark or Brazil, where health administration is fragmented, with federal authorities managing hospitals while municipalities manage primary care, the management of patients is very complicated. After developing a cross-sector collaboration model in Denmark, Dr Helena Dominguez, cardiologist in Bispebjerg-Frederiksberg Hospital and Associate Professor at the University […]

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Health & Medicine

Vitamin A: Seeing into the past, the present and the future

Why is Vitamin A critical to animal and human health, and what functions does it have in the body other than in vision? In this thought-provoking and informative interview, neuroscientist and Professor at Harvard University John Dowling takes us through the history of research into the topic, from the first mention of night blindness in 3500 BC to current and […]

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Health & Medicine

Diagnosing Sjögren’s syndrome with salivary gland ultrasound

Dr Juan Carlos Nieto-González from the Hospital General Universitario Gregorio Marañón has provided support for the utilisation of salivary gland ultrasound (SGUS) in diagnosing and assessing Sjögren’s syndrome in several published research papers. When compared with other diagnostic tools, SGUS is non-invasive, widely available in hospitals, and does not use any ionising radiation. It can also be used to diagnose […]

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Health & Medicine

Quality benchmarks identified for laboratory medicine mobile apps

Dr Snežana Jovičić and her colleagues from the EFLM “Patient Focused Laboratory Medicine” Working Group (PFLM-WG) have identified several benchmarks for quality evaluation of patient-oriented laboratory medicines apps. These include referencing information to ensure trustworthiness, appropriate graphics for knowledge supplementation, and simple explanations of laboratory test results. This ensures the empowerment of patients in understanding their own medical condition. These […]

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Health & Medicine

Dihydromyricetin shows promise as anxiety disorder treatment

Anxiety disorders are one of the most common mental illnesses, and social isolation can be a major source of contributing stress. Medications to treat these disorders, such as benzodiazepines, are available; however, they come with a range of downsides. In a recent study in mice, Prof Jing Liang’s team at the USC School of Pharmacy in the US discovered that […]

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Health & Medicine

Regression models using parametric pseudo-observations

The statistical analysis of survival data is the focus of research being carried out by Martin Nygård Johansen, a biostatistician at Aalborg University Hospital, Denmark, and his colleagues. Some patients’ actual survival times are not observed during a clinical study and are said to be censored. This research offers a new way to transform such time-to-event data into a dataset without censoring. […]

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Health & Medicine

Human Leukocyte Antigens: The missing link in Alzheimer’s disease etiology

Alzheimer’s disease is a huge socioeconomic burden in developed countries. Recently, viral infections such as the herpes virus have been implicated in Alzheimer’s disease risk. However, it is unclear what the link between the two is. Professor Lisa M. James of the University of Minnesota, in collaboration with Dr Apostolos Georgopoulos and Dr Spyros Charonis, has utilised computational biology to […]

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