Tag: ATO

Unlocking the mechanism of action of arsenic trioxide in leukaemia

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Image of cells under a microscope. One cell is much larger and purple, with a green arrow pointing to it. Researchers have identified the mechanism behind treatment for APL (a type of leukaemia) with ATO - arsenic trioxide - and vitamin A.

The blood cancer acute promyelocytic leukaemia (APL) has recently been transformed from a fatal condition to a curable one, thanks to the development of treatments including vitamin A1 and arsenic trioxide (ATO). Although very effective, the mechanism of action of ATO has remained unclear until now. Changing this is Professor Paul B Tchounwou and his team at Jackson State University, […]

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