DNA molecular scissors as new cancer chemotherapeutics

DNA molecular scissors as new cancer chemotherapeutics

The discovery of efficient new metallodrugs with minimal side effects is urgently needed in cancer medicine. Associate Professor Andrew Kellett and Dr Creina Slator, Dublin City University, Ireland, have employed ‘click chemistry’ to generate new copper DNA molecular scissors with anticancer and gene editing properties. Their molecules have coordinated metal centres and mimic the action of natural products that cause […]

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Producing the first functioning synthetic DNA using click chemistry

Gene-editing

Click chemistry revolutionised our ability to create custom proteins, so could it do the same for DNA? Professor Tom Brown at the University of Oxford and Professor Afaf El-Sagheer at the University of Oxford and Suez University are performing truly groundbreaking research into the application of ‘click chemistry’ bioconjugation techniques to DNA. Their technique allows the creation of DNA and […]

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