Tag: cancer
Novel cancer therapeutics could target ion channels
Although gynaecological cancers are amongst the most lethal cancers in women, treatments for the advanced stages of these cancers are scarce. Dr Saverio Gentile at the University of Illinois Cancer Center has been researching potassium ion channels as a potential target for novel cancer therapeutics. He has found that the use of potassium channel activators greatly reduced cell motility, tumour […]
The role of extra chromosomal circular DNA in rapid adaption to glyphosate resistance in pigweed
Plants, like other living organisms, have genetic stress-avoidance mechanisms that allow them to become resistant to specific chemicals when continuously exposed to them. Dr Christopher Saski from Clemson University and Dr William Molin from the U.S. Department of Agriculture are researching the extrachromosomal circular DNA (eccDNA) structure known as the replicon of pigweed, which contains the EPSPS gene, the gene […]
Quality of life for family caregivers is impacted by satisfaction with care
Cancer has an emotional and physical impact on caregivers as well as patients. If relatives are not happy with the care they are able to provide for the patient, this can impair their quality of life. Dr Miki Morishita-Kawahara at the Tokyo Women’s Medical University aims to understand better the factors that influence the quality of life of family caregivers […]
Capturing three-dimensional cell structure with X-ray tomography
Seeing cells is no easy task. Most cells are smaller than a tenth of the size of a human hair, making them impossible to see by eye. Optical microscopes, with the help of cell-staining to colour cells, can help us peer into the invisible world of cells. However, they only show us a 2D image of a very thin slice […]
Identifying the mitochondrial DNA mutations that cause cancer
Mutations that affect the mitochondrial DNA may play a key role in cancers. However, the exact mutations that are involved in cancer are still unknown. Dr Fatimata Mbaye and collaborators, from the University of Dakar in Senegal examined the sequences of two regions of the mitochondrial genome to identify and compare the mutations occurring in different cancers. Understanding the relationship […]
Overcoming resistance to cancer immunotherapy
Immunotherapy, which uses the body’s own immune system to fight cancer, is a great step forward in cancer treatment. Unfortunately, however, it is currently ineffective in most patients. This resistance can be caused by a type of cell called a cancer-associated fibroblast, which builds protective defences around tumours. In a recent study, Professor Gareth Thomas and his team at the […]
The adaptive cancer cell: How metastases evolve to resist treatment
Species adapt to survive in a changing environment through the process of evolution. Evolutionary processes can also take place at the cellular level. Dr Sarah Amend of Johns Hopkins University, Baltimore, USA, is investigating poly-aneuploid cancer cells (PACCs). These large, DNA-laden cells, which are more common in metastatic cancer, develop evolvability: the capacity to evolve. Dr Amend believes that targeting […]
Transtympanic injections to prevent hearing loss caused by cisplatin
Dr Sofia Waissbluth from The Pontificia Universidad Católica de Chile is specialised in otolaryngology (conditions of the head and neck). She has reviewed clinical trials that use transtympanic injections to prevent hearing loss caused by the chemotherapeutic agent cisplatin. To date there is no ‘one-shot’ solution to protect or cure patients from hearing loss. However, combinational therapy using transtympanic injections […]
Innovation in oncology drug development: A focus on patient benefits
Innovation in oncology drug development is driving more efficient and effective development of new cancer treatments. This innovation is providing cancer patients unprecedented access to new therapies. Dr Brian Huber, Vice President of Therapeutic Areas, Drug Development and Consulting at ICON and Matthew Huber, a scientist in the emerging biotechnology sector focused on developing innovative oncology medicines, have conducted a […]
Placental immune editing switches (PIES) and cancer progression
Exceptional mechanisms have evolved over millions of years to allow the foetus to grow directly inside the mother’s womb. These mechanisms, named placental immune editing switches, are orchestrated by the placenta and are responsible for locally switching off the mother’s immune system to protect the foetus. However, Dr Miguel Hernández-Bronchud from Clínica Corachan in Barcelona, suggests that the existence of […]