Targeted protein degradation: A new direction for treatment of diseases

Targeted protein degradation: A new direction for treatment of diseases

Many illnesses are currently treated with drugs that block the action of disease-causing proteins. Often, these drugs work well initially, but over time can become toxic or less effective. A new class of therapeutics called protein degraders, including proteolysis targeting chimeras (‘PROTACs’) and molecular glues shows promise to overcome these challenges. They do so by targeting the disease-causing protein for destruction, […]

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