methotrexate Archives

Managing lymphoproliferative disorders in patients with rheumatoid arthritis

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Lymphoproliferative disorders (LPDs) are characterised by the abnormal proliferation of lymphocytes – a white blood cell in the immune system. LPDs are a notable complication during the treatment of rheumatoid arthritis (RA), an autoimmune condition. In Japan, the incidence of LPDs in RA patients is high and the management and treatment strategies for these patients has been challenging. Dr Masao Tanaka from the Kyoto University […]

Therapeutic drug monitoring of methotrexate in disease

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Professor Dr Robert de Jonge, Dr Gerrit Jansen, Ittai Muller MSc and Helen Gosselt MSc, Amsterdam University Medical Center, are pioneering analytical approaches which can be used to understand why patients respond differently to the anchor drug used to manage rheumatoid arthritis, called methotrexate. Their work has begun to unravel the key factors behind the mechanism of action of methotrexate, […]