Tag: Nonhomologous DNA end joining

Artemis:DNA-PKcs: A new drug target for cancer treatment?

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Watanabe studies the molecular mechanisms of NHEJ and describes the basal state Artemis:DNA-PKcs complex for the first time.

Cells encounter DNA double-strand breaks (DSBs) every day. Because they can lead to loss of genetic information, DSBs must be repaired. Nonhomologous DNA end joining (NHEJ) is the major pathway for repairing DSBs, and the key enzymes include Artemis nuclease and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). For the first time, Dr Go Watanabe and his team from the University […]

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