DNA untangled: Topoisomerase enzymes remove our genetic knots

DNA transcription

Topoisomerases are enzymes that are abundantly present in our cells and can temporarily cut and rejoin our DNA to remove knots and tangles that form during important biological processes. If they fail to do their job, cells may die. Some anti-cancer and anti-bacterial drugs alter this natural process to eliminate unwanted cells. Dr Neil Osheroff, professor of Biochemistry and Medicine […]

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From beer to brains: how yeast molecular genetics prove the importance of introns

A research article highlighting the importance of intron retention, using the GCR1 gene found in yeast as a model system.

Scientific discoveries often come from the most unlikely of places, and Dr Tracy Johnson’s work is no exception. Using a yeast system typically used to make beer or bread, Dr Johnson and her team at UCLA have uncovered important genetic findings that could highlight the importance of intron retention during gene expression. Her research looks at the science of gene […]

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