DNA untangled: Topoisomerase enzymes remove our genetic knots

DNA transcription

Topoisomerases are enzymes that are abundantly present in our cells and can temporarily cut and rejoin our DNA to remove knots and tangles that form during important biological processes. If they fail to do their job, cells may die. Some anti-cancer and anti-bacterial drugs alter this natural process to eliminate unwanted cells. Dr Neil Osheroff, professor of Biochemistry and Medicine […]

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