Tag: gene mutations

Disruption of amyloid β-protein processing drives Alzheimer’s

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Professor Michael S. Wolfe explored the issue whereby increased concentrations of this form of Aβ proteins does not always occur with disease-causing mutations, suggesting a different step in Aβ processing could be triggering Alzheimer’s

In the study of familial Alzheimer’s disease, a specific form of amyloid β-protein (Aβ) found in amyloid plaques has been the focus of many investigations as a key driver of disease. However, increased concentrations of this form of Aβ does not always occur with disease-causing mutations, suggesting a different step in Aβ processing could be triggering Alzheimer’s. Professor Michael S. […]

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