Human Leukocyte Antigens: The missing link in Alzheimer’s disease etiology

Viral infections such as the herpes virus have been implicated in Alzheimer’s disease risk.

Alzheimer’s disease is a huge socioeconomic burden in developed countries. Recently, viral infections such as the herpes virus have been implicated in Alzheimer’s disease risk. However, it is unclear what the link between the two is. Professor Lisa M. James of the University of Minnesota, in collaboration with Dr Apostolos Georgopoulos and Dr Spyros Charonis, has utilised computational biology to […]

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Mutant protein in Siamese cats may be involved in neurodegenerative disorders

Dr Niesman studies mutant tyrosinase in feline brain cells.

Siamese cats and humans share the same pathology when it comes to neurodegenerative disorders, such as Alzheimer’s disease. Dr Ingrid Niesman, based at San Diego State University, USA, believes it’s all down to a mutation in a protein called tyrosinase. The researcher wants to understand the impact of this malfunctioning protein, as well as use these cats as a basis […]

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Neuronal cultures to study the brain and neurological disorders

Neuronal cultures to study the brain and neurological disorders

Understanding the brain is essential, for example to treat neurological disorders that affect one in six people worldwide. However, studying the brain is challenging: it is so complex and difficult to access. Cell biologist Dr Daniel Tornero and neurophysicist Dr Jordi Soriano, from the University of Barcelona, developed neuronal cultures that can be used to study mechanisms involved in brain […]

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Extracellular vesicles: Insights into mechanisms underlying Alzheimer’s disease

The prion protein and the GABARAP protein are both observed in EVs.

Dr Aida Serra of the IMDEA Research Institute Food & Health Sciences in Madrid, Spain, together with Dr Siu Kwan Sze of Nanyang Techological University, Singapore, and Dr Xavier Gallart-Palau at the Institut Investigació Sanitària Pere Virgili, Tarragona, Spain, is driving forward research concerning the mechanisms underlying Alzheimer’s disease (AD) and its progression. To do so, they are focusing their […]

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What can peptide-coated nanoparticles tell us about the causes of dementia?

Kazushige Yokoyama, Professor of Chemistry at the State University of New York Geneseo College, investigates how peptides interact. Along with Akane Ichiki, an undergraduate student at the institution, his team have been investigating the peptides involved in fibrillogenesis, the process which occurs in the brain to form aggregates responsible for some of the symptoms involved in neurodegenerative diseases like Alzheimer’s […]

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It’s not only about neurons – How the UK Dementia Research Institute is facilitating an interdisciplinary approach in the global fight against neurodegenerative conditions

It’s not only about neurons – How the UK Dementia Research Institute is facilitating an interdisciplinary approach in the global fight against neurodegenerative conditions

Dementia is the world’s biggest challenge in terms of social and health costs. In the UK, we’re projected to have 1 million dementia patients in 2020 at a cost of £26bn; by 2040, costs are projected to reach £55bn. Globally, 50 million people are affected by dementia and this will increase to 152 million by 2050. But, looking beyond the statistics, […]

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Benefits of a diet with walnuts in Alzheimer’s disease

Benefits of a diet with walnuts in Alzheimer’s disease

Alzheimer’s disease is a severe neurodegenerative disorder, responsible for 60-70% of cases of dementia. The most common symptoms are memory loss, disorientation and loss of cognition. To date, there is no known cure for this disease, but Dr Abha Chauhan, based at the New York State Institute for Basic Research in Developmental Disabilities, New York, USA, has shown how supplementation with walnuts in […]

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Virtual navigation exposes the reality of Alzheimer’s disease onset

This science research article explores Prof Moussavi’s work as she aims to find new methods for early diagnosis and treatment of Alzheimer’s disease.

Prof Zahra Moussavi from the Faculty of Engineering at the University of Manitoba in Canada has developed a novel method of assessing patients for Alzheimer’s disease. Using a virtual reality environment to measure spatial awareness, she has shown key differences between control and patient groups, leading to pilot studies for effective early treatment. Prof Zahra Moussavi became interested in early […]

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