IBD Archives

Novel immunoassays for detection of faecal calprotectin and neutrophil extracellular traps in the gut

Written by

Dr Fagerhol has developed new methods for the assessment of faecal calprotectin, a valuable non-invasive biomarker for inflammatory bowel disease (IBD) that is increasingly common.

Faecal calprotectin (CP) is a valuable biomarker for inflammatory bowel disease (IBD). Nevertheless, commercial assays do not display comparable clinical sensitivities and specificities. Dr Magne Fagerhol at the Oslo University Hospital, Norway, explored the structure of faecal CP to understand the sources of variation and developed new monoclonal antibody mixtures and immunoassay procedures that improved the sensitivity. Moreover, Fagerhol demonstrated […]

Inflammatory bowel disease and epithelial barrier function

Written by

Inflammatory bowel disease (IBD) occurs when the epithelial cells lining the gut become weakened, allowing gut microbes to activate immune cells. Gut barrier weakening can be caused by a loss of function of the PTPN2 gene. Professor Declan McCole of the University of California, Riverside and various collaborators have extensively researched the role of the epithelial barrier in IBD, the […]