inflammatory bowel disease Archives

Novel immunoassays for detection of faecal calprotectin and neutrophil extracellular traps in the gut

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Dr Fagerhol has developed new methods for the assessment of faecal calprotectin, a valuable non-invasive biomarker for inflammatory bowel disease (IBD) that is increasingly common.

Faecal calprotectin (CP) is a valuable biomarker for inflammatory bowel disease (IBD). Nevertheless, commercial assays do not display comparable clinical sensitivities and specificities. Dr Magne Fagerhol at the Oslo University Hospital, Norway, explored the structure of faecal CP to understand the sources of variation and developed new monoclonal antibody mixtures and immunoassay procedures that improved the sensitivity. Moreover, Fagerhol demonstrated […]

The role of CD83: Autoimmunity, transplantation and beyond

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Professor Alexander Steinkasserer is based at the Department of Immune Modulation, University Hospital, Erlangen. His research interests are focused on the immune system, with the long-term aim to develop new therapeutic strategies for patients suffering from autoimmune disorders or in need of transplantation. Along with his colleagues at the department of Immune Modulation, Professor Steinkasserer has shed much light on […]

A novel therapy could help patients with active Crohn’s disease

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Dr Jahnsen's study aims to improve symptoms experienced by patients with Crohn’s disease, such as abdominal pain.

Professor Jørgen Jahnsen and PhD student Kristian Espeland of Akershus University Hospital and University of Oslo are responsible for a new clinical trial which aims to improve symptoms and control the inflammation of Crohn’s disease using Gliolan medication in combination with blue-light photopheresis. This approach will selectively cause the death of pro-inflammatory cells which contribute to the inflammatory bowel disease, […]