Precision medicine Archives

Simple blood tests could predict immunotherapy effectiveness

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Dr George Laliotis and his team predict the response of head and neck squamous cell carcinoma (HNSCC) patients to immunotherapy using precision-medicine techniques.

Despite the extensive use of immunotherapy in patients suffering from head and neck squamous cell carcinoma, this therapy has significant limitations. Not everyone responds to treatment and current therapies can have serious adverse side effects. When working at the Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, USA, Dr George Laliotis and his team discovered that biochemical factors, measured […]

Using genetics to guide treatment of arterial hypertension with Rostafuroxin

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Many genetic variants have been found to be associated with blood pressure level.

Primary hypertension is a major health concern and can cause serious cardiac, renal and brain complications responsible for about 10% of worldwide health burden and costs. The development of hypertension is triggered by genetic factors that, in turn, are modulated by biological and environmental factors. Many drugs are available for the treatment of hypertension, but none target the underlying genetic […]

Fluoxetine (Prozac) use in children: working towards a customised approach

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Science article about the behavioural effects of fluoxetine (Prozac) on children

Dr Mari Golub from the Environmental Toxicology Department at the University of California at Davis, has recently completed a five-year research project looking at the behavioural effects of fluoxetine (Prozac) on brain development. Her findings, which have so far been published in eight academic papers, supplement information on the safety of fluoxetine use in children, and show for the first […]