Cilia, asymmetry, and genetic disease

Zebra fish

The length and movement of motile cilia – microscopic hair-like organelles on the outside of our cells – have a remarkable effect on the asymmetric development of embryos, allowing organs to grow in the correct places in our bodies. Dr Susana Lopes and her team at the LYSOCIL project are investigating rare genetic diseases affecting the cilia, and how these […]

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X-ray histotomography: Characterising every cell of a whole organism

Histology is a powerful technique to study thin slices of tissue samples.

Histology is a powerful technique used to distinguish normal and abnormal cells and tissue. In practice, only a small sampling of thin, 2-dimensional slices is readily available for diagnosis. In contrast, micro-CT allows full-volume, 3-dimensional (3D) imaging of biological samples. By optimising micro-CT, a multidisciplinary team led by Dr Keith Cheng from Pennsylvania State University created X-ray histotomography, a technique […]

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