Regulators of protein degradation as potential treatments for neurodegenerative disease

Beta amyloid plays a fundamental role in disease pathogenesis in Alzheimer’s.

Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, are characterised by the accumulation of misfolded and damaged protein aggregates. Normally, proteins that are damaged or malfunctioning are destroyed by the ubiquitin proteasome system (UPS). However, the UPS itself is impaired in several instances of neurodegenerative diseases. Dr David Smith and his team at the School of Medicine, University of West […]

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