When the body turns against itself: Amyloid-based diseases

Amyloid-based diseases

Often, the body is its own worst enemy. Diseases such as cancer are caused by faults in the natural replication processes of our own cells. It is thought that both Parkinson’s and Alzheimer’s disease may be caused by amyloids – aggregates of our own proteins that can disrupt nerve signalling and other functions. Dr H. Robert Guy of Amyloid Research […]

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Maryland Stem Cell Research Fund: Cutting-edge regenerative medicine

graphic representing stem cell research

The Maryland Stem Cell Research Fund (MCSRF) is devoted to developing and supporting innovative research into all aspects of stem-cell-based technologies. Through its diverse program structure, the MSCRF is intimately involved in every stage of the stem cell journey – from pre-clinical lab discovery to clinical patient trials. Importantly, it remains forward thinking, ensuring the next generation of researchers have […]

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Using β3 integrin to control reactive astrocytes, and help neurons survive

brain scan from a rat

The long-ignored astrocyte is of more interest than ever in neuroscience. When the central nervous system is damaged, astrocytes undergo astrogliosis, morphing into reactive astrocytes to protect neurons from further damage. But, as it turns out, this process could be doing more harm than good by not allowing damaged neurons to mend themselves. Professor Lisette Leyton of the University of […]

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The trials and tribulations in the drug discovery cycle: A particular case for Alzheimer’s disease

The trials and tribulations in the drug discovery cycle

As people live longer lives, the spectre of Alzheimer’s disease will only grow. Scientists now know that the amyloid beta (Aβ) peptides are important for treating Alzheimer’s, particularly Aβ42 which aggregates into the amyloid plaques that trigger the disease. Researchers have been looking to target γ-secretase – the enzyme that creates pathogenic Aβ42 affecting the relative abundance of short Aβ […]

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An age-old problem: How SENS Research Foundation is looking at age-related disease in a new way

SENS Research Foundation funds innovative gerontology research around the world.

Despite time, energy and money being poured into age-related disease research around the world, humans are yet to find cures for illnesses such as Alzheimer’s, cardiovascular disease and diabetes. SENS Research Foundation believe this is because current research is approaching the problem from the wrong angle. Research Outreach found out more from the Foundation’s Chief Science Officer and co-founder Dr […]

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Regulators of protein degradation as potential treatments for neurodegenerative disease

Beta amyloid plays a fundamental role in disease pathogenesis in Alzheimer’s.

Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, are characterised by the accumulation of misfolded and damaged protein aggregates. Normally, proteins that are damaged or malfunctioning are destroyed by the ubiquitin proteasome system (UPS). However, the UPS itself is impaired in several instances of neurodegenerative diseases. Dr David Smith and his team at the School of Medicine, University of West […]

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New Toolkits for Positron Emission Tomography

PET scanners make use of radioactive tracers.

Positron emission tomography (PET) is a powerful imaging technique that uses radiotracers injected into the body to look at biology in tissues and cells, making it an important tool in biomedical research and drug development. Dr Victor Pike, Chief of the PET Radiopharmaceutical Sciences Section of the Molecular Imaging Branch at the National Institute of Mental Health in the U.S., […]

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