Regulators of protein degradation as potential treatments for neurodegenerative disease

Beta amyloid plays a fundamental role in disease pathogenesis in Alzheimer’s.

Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, are characterised by the accumulation of misfolded and damaged protein aggregates. Normally, proteins that are damaged or malfunctioning are destroyed by the ubiquitin proteasome system (UPS). However, the UPS itself is impaired in several instances of neurodegenerative diseases. Dr David Smith and his team at the School of Medicine, University of West […]

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What can peptide-coated nanoparticles tell us about the causes of dementia?

Kazushige Yokoyama, Professor of Chemistry at the State University of New York Geneseo College, investigates how peptides interact. Along with Akane Ichiki, an undergraduate student at the institution, his team have been investigating the peptides involved in fibrillogenesis, the process which occurs in the brain to form aggregates responsible for some of the symptoms involved in neurodegenerative diseases like Alzheimer’s […]

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Benefits of a diet with walnuts in Alzheimer’s disease

Benefits of a diet with walnuts in Alzheimer’s disease

Alzheimer’s disease is a severe neurodegenerative disorder, responsible for 60-70% of cases of dementia. The most common symptoms are memory loss, disorientation and loss of cognition. To date, there is no known cure for this disease, but Dr Abha Chauhan, based at the New York State Institute for Basic Research in Developmental Disabilities, New York, USA, has shown how supplementation with walnuts in […]

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Fruit flies help shed light on drug discovery for ALS

Fruit flies help shed light on drug discovery for ALS

Amyotrophic lateral sclerosis (ALS) is a devastating and incurable neurodegenerative disease that affects people in adulthood. It leads to the death of neurons involved in muscle control, eventually affecting almost all facets of the body, including walking, swallowing and breathing. Drs Nancy Bonini and Leeanne McGurk at the University of Pennsylvania are using fruit flies, mammalian cellular systems like neurons, […]

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