Connectase: An enzyme that fuses proteins in a specific manner

A row of test tubes

Dr Adrian Fuchs, post-doctoral researcher at the Max Planck Institute for Developmental Biology, and his team of researchers have discovered an enzyme that can fuse two proteins at specific recognition sites. This reaction enables the engineering of proteins with new characteristics, for example by labeling them with a detectable marker or by manipulating their interaction behaviour. Such applications are useful […]

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Regulators of protein degradation as potential treatments for neurodegenerative disease

Beta amyloid plays a fundamental role in disease pathogenesis in Alzheimer’s.

Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, are characterised by the accumulation of misfolded and damaged protein aggregates. Normally, proteins that are damaged or malfunctioning are destroyed by the ubiquitin proteasome system (UPS). However, the UPS itself is impaired in several instances of neurodegenerative diseases. Dr David Smith and his team at the School of Medicine, University of West […]

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Protein as a Unifying Metric for Carbon Footprinting Livestock

The GHG-protein indicator can be used to inform consumers and producers about the impact of red meat consumption on GHG levels in Canada.

Agriculture and livestock production contribute significantly to greenhouse gas emissions and climate change. To reduce these emissions, some environmental groups advocate reducing the amount of red meat that we consume. James Dyer and Raymond Desjardins, Agriculture and Agri-Food Canada (AAFC), were interested in the impact that reducing red meat, diversifying meat consumption and changing cattle diets could potentially have on […]

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How new RNA genes are born

Dr Delihas made an unexpected discovery of an ancestral DNA repeat sequence.

The study of gene birth and evolution focuses on the identification of ancestral genetic sequences, highly conserved during evolution, that can serve as a foundation for gene development. Nicholas Delihas, Professor Emeritus at the Renaissance School of Medicine at Stony Brook University, New York, has identified one such ancestral element and presented data and a model to show how new […]

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