Curing the incurable: RNA isoforms may hold the key to defeating Alzheimer’s disease

Alzheimer’s disease causes excessive neuronal cell death.

Groundbreaking research on RNA isoforms in Alzheimer’s disease (AD) has revealed another layer of genetic complexity that has been previously overlooked. Using cutting-edge sequencing technology, Dr. Mark Ebbert and colleagues at the Sanders-Brown Center on Aging at the University of Kentucky, USA, performed a detailed analysis of RNA isoforms in the human brain. They discovered multiple, previously unknown RNA isoforms […]

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A blow to the head impairs the autoregulation of brain blood flow: Neural consequences

Professor Akos Koller investigates the impact of traumatic brain injuries on cerebral blood flow and the ensuing consequences on brain function

Billions of cells make up the human brain. To keep this super-computer functioning, a carefully autoregulated blood supply provides oxygen and nutrients and removes waste products from the brain cells. In addition, cerebral circulation is involved in the regulation of the pressure inside the cranium. But what happens if this autoregulatory process is disrupted? Building on years of research into […]

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