The trials and tribulations in the drug discovery cycle: A particular case for Alzheimer’s disease

The trials and tribulations in the drug discovery cycle

As people live longer lives, the spectre of Alzheimer’s disease will only grow. Scientists now know that the amyloid beta (Aβ) peptides are important for treating Alzheimer’s, particularly Aβ42 which aggregates into the amyloid plaques that trigger the disease. Researchers have been looking to target γ-secretase – the enzyme that creates pathogenic Aβ42 affecting the relative abundance of short Aβ […]

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Human Leukocyte Antigens: The missing link in Alzheimer’s disease etiology

Viral infections such as the herpes virus have been implicated in Alzheimer’s disease risk.

Alzheimer’s disease is a huge socioeconomic burden in developed countries. Recently, viral infections such as the herpes virus have been implicated in Alzheimer’s disease risk. However, it is unclear what the link between the two is. Professor Lisa M. James of the University of Minnesota, in collaboration with Dr Apostolos Georgopoulos and Dr Spyros Charonis, has utilised computational biology to […]

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Mutant protein in Siamese cats may be involved in neurodegenerative disorders

Dr Niesman studies mutant tyrosinase in feline brain cells.

Siamese cats and humans share the same pathology when it comes to neurodegenerative disorders, such as Alzheimer’s disease. Dr Ingrid Niesman, based at San Diego State University, USA, believes it’s all down to a mutation in a protein called tyrosinase. The researcher wants to understand the impact of this malfunctioning protein, as well as use these cats as a basis […]

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Managing behavioural symptoms of dementia in Latinos

Managing behavioural symptoms of dementia in Latinos

Dr Diana Lynn Woods, Azusa Pacific University, has dedicated her research to the greater understanding of dementia and the methods used to treat behavioural symptoms of dementia. Her recent work has focused on Latinos with dementia who exhibit behavioural symptoms of dementia and ways to incorporate genetic and cultural factors into intervention strategies. Humans are living longer than ever. However, […]

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Extracellular vesicles: Insights into mechanisms underlying Alzheimer’s disease

The prion protein and the GABARAP protein are both observed in EVs.

Dr Aida Serra of the IMDEA Research Institute Food & Health Sciences in Madrid, Spain, together with Dr Siu Kwan Sze of Nanyang Techological University, Singapore, and Dr Xavier Gallart-Palau at the Institut Investigació Sanitària Pere Virgili, Tarragona, Spain, is driving forward research concerning the mechanisms underlying Alzheimer’s disease (AD) and its progression. To do so, they are focusing their […]

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What can peptide-coated nanoparticles tell us about the causes of dementia?

Kazushige Yokoyama, Professor of Chemistry at the State University of New York Geneseo College, investigates how peptides interact. Along with Akane Ichiki, an undergraduate student at the institution, his team have been investigating the peptides involved in fibrillogenesis, the process which occurs in the brain to form aggregates responsible for some of the symptoms involved in neurodegenerative diseases like Alzheimer’s […]

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It’s not only about neurons – How the UK Dementia Research Institute is facilitating an interdisciplinary approach in the global fight against neurodegenerative conditions

It’s not only about neurons – How the UK Dementia Research Institute is facilitating an interdisciplinary approach in the global fight against neurodegenerative conditions

Dementia is the world’s biggest challenge in terms of social and health costs. In the UK, we’re projected to have 1 million dementia patients in 2020 at a cost of £26bn; by 2040, costs are projected to reach £55bn. Globally, 50 million people are affected by dementia and this will increase to 152 million by 2050. But, looking beyond the statistics, […]

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High pressure talk with Professor Rhian Touyz

At the Institute of Cardiovascular and Medical Science (ICAMS) at the University of Glasgow, world-renowned researchers are dedicated to discovering mechanisms of cardiovascular disease (CVD) in their quest to advance new treatments and to develop improved prevention, management and diagnostic strategies. Professor Rhian Touyz takes an innovative new approach to preventing CVD by conducting extensive research into other intricately linked […]

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