microRNA Archives

Using genetic signatures to better classify spinal neurons

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Professor Samuel Pfaff builds on previous research to develop genetic tags that can be used to classify spinal neurons

Professor Samuel Pfaff at the Salk Institute for Biological Studies builds on previous work revealing important principles related to neural development, gene regulation, axon guidance and connectivity, and spinal motor circuit function. Spinal neurons were traditionally grouped into around 12 cardinal classes – but this doesn’t describe their full diversity. Now, the Salk Institute for Biological Studies team has developed […]

MicroRNAs as promising biomarkers and therapeutic tools in hereditary hemorrhagic telangiectasia

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Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder that results in potentially fatal blood vessel abnormalities. Currently, there is no cure or universally effective treatment for the condition, which remains underfunded and underdiagnosed. MicroRNAs have emerged as new biomarkers for human diseases and hold great promise for the improved diagnosis and treatment of HHT. A recent review publication by Anthony […]

Direct cardiac reprogramming to regenerate the heart

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Infarction causes the loss of a consequent number of cardiac muscle cells. Unable to self-regenerate, these cells are replaced by fibroblasts. This can lead to heart failure. Priyadharshni Muniyandi, doctoral researcher and Dr M. Sheikh Mohamed, Associate Professor at the Bio-Nano Electronics Research Centre, Toyo University, work on direct cardiac reprogramming. Their technique uses microRNA encapsulated in a non-viral nanocarrier: […]