Regulating RNA interference by modifying RNA backbone with amides

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Professor Rozners and his team use nucleic acid chemistry to improve RNA-based technologies, modifying RNA backbone with amides

Professor Eriks Rozners and colleagues at Binghamton University in New York, USA, are using innovative nucleic acid chemistry to modify RNA-based technologies such as RNA interference (RNAi) and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) to enhance their utility in molecular biology. These technologies suffer from off-target effects that limit their clinical utility. By replacing phosphates in the backbone with […]

Modelling the growth of minerals

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What do precious gems, seashells, and bones have in common? The answer is minerals. Minerals are chemically complex solids that are mostly formed naturally by Earth’s and space’s geological processes but can also be produced by many living species, including humans. Dr Raffaella Demichelis, at Curtin University, Australia, is using computational chemistry to see how these minerals form and how […]