School of Medicine Archives

Regulators of protein degradation as potential treatments for neurodegenerative disease

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Beta amyloid plays a fundamental role in disease pathogenesis in Alzheimer’s.

Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, are characterised by the accumulation of misfolded and damaged protein aggregates. Normally, proteins that are damaged or malfunctioning are destroyed by the ubiquitin proteasome system (UPS). However, the UPS itself is impaired in several instances of neurodegenerative diseases. Dr David Smith and his team at the School of Medicine, University of West […]

A measure to predict critical errors in open emergency surgery

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Medical errors are a leading cause of worldwide deaths. Surgeons are sometimes required to carry out procedures that they do not perform frequently, which leads to surgical errors that can have severe consequences for patients. To confront this issue, Professor Colin Mackenzie, Emeritus Professor at the University of Maryland, School of Medicine, developed with his team, the Trauma Readiness Index […]