adenosine triphosphate Archives

The heart of the matter: Elamipretide in the treatment of Barth syndrome

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Dr Hani Sabbah has spent a decade researching the potential of elamipretide as a therapy for the Barth syndrome.

Barth syndrome (BTHS) is an ultra-rare but debilitating genetic disease affecting cell mitochondria. High infant mortality due to cardiac complications and a weakened immune system significantly decrease life expectancy. Current medications treat symptoms but not the cause, leaving an unmet clinical need to develop effective treatments that target the underlying pathology. Dr Hani N Sabbah, Professor of Medicine at Wayne […]

Energy transformation in living cells: The role of vitamin C

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Professor János Hunyady has formulated how ATP is synthesised in cells, the energy present in cells, and how the structures for energy transformation regulate ATP production in aerobic and anaerobic conditions

The biochemical processes responsible for energy production in cells and for its utilisation in cellular metabolism have been studied extensively. Although several details of how these complex chemical reactions take place have progressively been clarified, far less is known about the structure of the biomolecules involved and their interactions. Professor emeritus János Hunyady, from the University of Debrecen, Hungary, is […]

The serendipitous discovery of a new green chemistry method

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Dr Petri Turhanen was working on a synthesis of a modified version of the biological molecule adenosine triphosphate (ATP), when he discovered that the cation exchange resin he was using was unintentionally producing another molecule. Closer investigation revealed that the molecule had been iodinated, meaning an iodine atom had been added. This specific reaction is challenging to perform using current […]

Controlling magnesium flux: a central role for the PRL-CNNM complex

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a science article about a newly discovered pathway (PRL-CNNM) that could help us use magnesium to help our understanding of cancer, metabolism, circadian rhythm and infectious disease.

Magnesium is an essential metal ion for human health. However, its ability to act as a supplementary therapy against disease is a poorly understood area of science. Professor Michel L. Tremblay and his team at McGill University in Montreal, Canada, are looking to change this though, and are currently investigating the role of the newly discovered pathway, PRL-CNNM, in controlling […]