antioxidants Archives

How oxidative stress contributes to neurodegenerative diseases

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Hyslop and Chaney use biochemical and computer molecular modelling to probe interaction between H2O2 and GAPDH to identify new molecular targets for treating neurodegeneration and neurodegenerative diseases.

The human brain relies on a constant energy supply that when compromised, neurodegenerative disease ensues, initially disrupting nerve cell communication followed by nerve cell death. Paul Hyslop and Michael Chaney investigate fundamental mechanisms driving neurodegenerative disease, to identify therapeutic interventions. They focus on how an enzyme integral to energy supply to nerve cells, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) – is inhibited and […]

Pulmonary tuberculosis: Biomarker discovery in the quest for new therapies

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Dr Esmeralda Juárez and her team research tuberculosis disease mechanisms through biomarker discoveries.

Pulmonary tuberculosis (TB) presents a significant health burden worldwide with treatments remaining suboptimal. In the pursuit of new or adjunctive therapies, Esmeralda Juárez and researchers at the Department of Research in Microbiology at the National Institute of Respiratory Diseases in Mexico City investigate the lungs’ immune-response mechanisms to TB infection. By sampling the breath of TB patients using a non-invasive […]