How oxidative stress contributes to neurodegenerative diseases

Hyslop and Chaney use biochemical and computer molecular modelling to probe interaction between H2O2 and GAPDH to identify new molecular targets for treating neurodegeneration and neurodegenerative diseases.

The human brain relies on a constant energy supply that when compromised, neurodegenerative disease ensues, initially disrupting nerve cell communication followed by nerve cell death. Paul Hyslop and Michael Chaney investigate fundamental mechanisms driving neurodegenerative disease, to identify therapeutic interventions. They focus on how an enzyme integral to energy supply to nerve cells, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) – is inhibited and […]

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