heart Archives

The heart of the matter: Elamipretide in the treatment of Barth syndrome

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Dr Hani Sabbah has spent a decade researching the potential of elamipretide as a therapy for the Barth syndrome.

Barth syndrome (BTHS) is an ultra-rare but debilitating genetic disease affecting cell mitochondria. High infant mortality due to cardiac complications and a weakened immune system significantly decrease life expectancy. Current medications treat symptoms but not the cause, leaving an unmet clinical need to develop effective treatments that target the underlying pathology. Dr Hani N Sabbah, Professor of Medicine at Wayne […]

Controlling heart rhythm reduces adverse outcomes in atrial fibrillation

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Around 2% of the European population suffer from atrial fibrillation, a heart condition characterised by a change in heart rhythm that increases the risk of serious health complications. Currently, therapies to directly address the arrhythmia are not used for all patients. The Atrial Fibrillation Network Association (AFNET) was the responsible organisation for the EAST-AFNET 4 trial, which set out to […]

Uncovering critical cell death mechanisms for novel cardioprotective therapies

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Mitochondria are required to produce the vast amount of energy that is required for the cell to beat.

Cell death is part of a natural process by which old cells are replaced by new, but it can also result from disease or injury. There are still many aspects of this process which are not fully understood. The laboratory of Dr Jason Karch, Baylor College of Medicine, aims to increase comprehension of the mechanisms behind cell death. If these […]