Identifying the mitochondrial DNA mutations that cause cancer

Mutations that affect the mitochondrial DNA may play a key role in cancers. However, the exact mutations that are involved in cancer are still unknown. Dr Fatimata Mbaye and collaborators, from the University of Dakar in Senegal examined the sequences of two regions of the mitochondrial genome to identify and compare the mutations occurring in different cancers. Understanding the relationship […]

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Mitonucleons: A new chapter in the story of mitochondria?

The mitonucleon consists of multiple mitochondria.

Mitonucleons are a newly recognised type of mitochondrial superstructure. Consisting of multiple mitochondria enveloping chromatin, mitonucleons appear to be responsible for the development of unusual structures called spheroids. Dr Honoree Fleming of Castleton State College, Vermont, USA, has identified mitonucleons in human endometrial cells in vitro. Using microscopy, Dr Fleming has also observed mysterious structures called tubules, which appear to […]

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