Rheumatoid arthritis Archives

Why do women experience more chronic pain than men?

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Dr Singh investigates chronic pain, emphasising the need to understand the sex differences in chronic pain better.

Chronic pain is poorly managed by current healthcare systems, with limited treatments. However, little is known about chronic pain, especially in autoimmune diseases. Dr Gurmit Singh and colleagues at McMaster University, Canada, have investigated whether chronic pain should be considered an autoimmune disease and why chronic pain is more common in women. They have identified various explanations as to why women […]

Long-term outcomes in total knee arthroplasty (TKA) patients with rheumatoid arthritis (RA)

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Dr Yamashita studies the long-term outcomes of patients post-operative ability to walk outside after surgery to deal with rheumatoid arthritis

Due to the degeneration of the knee joint in individuals with rheumatoid arthritis (RA), walking becomes difficult. Total knee arthroplasty (TKA) can restore the ability to walk. Several reports have been published highlighting the survival rate of TKA in RA patients, however, no study has focused on the prospect of outdoor walking. Dr Fumiharu Yamashita and his team from the […]

Fragment-based design of isoquinoline derivatives as anti-inflammatory drugs

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Dr Masakazu Atobe and his colleagues have developed a methodology that can be applied to the discovery of effective drugs.

Fragment-based drug discovery (FBDD) is a well-established high-throughput screening method for drug generation. Fragment molecules used in FBDD tend to be structurally less complex than the compounds used in conventional high-throughput screening techniques. Dr Masakazu Atobe from Asahi Kasei Pharma Corporation in Japan and his colleagues have developed a methodology that can be applied to the discovery of effective drugs […]

The role of CD83: Autoimmunity, transplantation and beyond

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Professor Alexander Steinkasserer is based at the Department of Immune Modulation, University Hospital, Erlangen. His research interests are focused on the immune system, with the long-term aim to develop new therapeutic strategies for patients suffering from autoimmune disorders or in need of transplantation. Along with his colleagues at the department of Immune Modulation, Professor Steinkasserer has shed much light on […]

Case for the improvement of suboptimal care of gout patients in Hawai’i

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The level of care for gout patients in Hawai’i has been a subject of concern to stakeholders. A retrospective study of gout and rheumatoid arthritis patients who were 18 years and above within Hawai’i Pacific Health healthcare system between 2011 and 2017 were undertaken by Dr Sian Yik Lim MD, CCD, Rhmsus, a Doctor of Medicine, Pali Momi Medical Center, […]

Therapeutic drug monitoring of methotrexate in disease

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Professor Dr Robert de Jonge, Dr Gerrit Jansen, Ittai Muller MSc and Helen Gosselt MSc, Amsterdam University Medical Center, are pioneering analytical approaches which can be used to understand why patients respond differently to the anchor drug used to manage rheumatoid arthritis, called methotrexate. Their work has begun to unravel the key factors behind the mechanism of action of methotrexate, […]