Acoustic waves to brain signals: Identifying the gating spring

The inner workings of our ears have been well understood for some time, but there is still significant debate among researchers over how acoustic vibrations are converted into electrical brain signals. In his research, Dr Jim Hudspeth at The Rockefeller University sheds new light on the discussion, by studying the proteins which connect tiny vibrating hairs in the inner ear with […]

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DNA replication: Unravelling the secrets of the replisome

DNA replication: Unravelling the secrets of the replisome

Every cell needs to divide and produce more cells. This is an essential part of every living organism. The first step is to make a copy of its own DNA to pass on to daughter cells. This is known as DNA replication and has been the focus of Professor Michael O’Donnell’s lab for many years. The team, based at The Rockefeller University, New […]

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Raising antibodies against protein complexes

A health research article about Dr LaCava researches macromolecular interactions analyses, developing monoclonal antibodies capable of binding to protein complexes found in cancer cells.

Dr John LaCava of The Rockefeller University has identified a gap in the current availability of target-specific antibodies for the analysis of intracellular protein-protein interactions. Using the latest antibody production techniques, alongside immunoprecipitation and mass spectrometry, he aims to identify important interactions between transcription factors and other macromolecules which are implicated in disease. Proteins are vital for the inner workings […]

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