Health & Medicine

The role of IL-33 in preventing metabolic disease

Dr Amal Hasan is based at the Dasman Diabetes Institute, State of Kuwait. Her work looks at the mechanics behind the relationship between obesity and metabolic disease. In particular, Dr Hasan’s research has shed light on the involvement of a molecule called IL-33 in metabolic disease. IL-33 and its interactions with another molecule, ST2, may play a role in metabolic […]

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Health & Medicine

Dry needling could hold the key to relieving lower back pain

Lower back pain is a common health issue in adults. Many treatments, both conventional and alternative, are available. Dry needling is an alternative medicine technique that is gaining popularity among physical therapists and their patients. In an upcoming study, Dr Ulrike Mitchell of Brigham Young University, Provo, USA and her team will investigate the potential of dry needling to relieve […]

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Health & Medicine

Gestational diabetes: A novel detection strategy

Gestational diabetes is a complication arising in pregnancy that can lead to serious and lifelong health concerns for the mother and child. Currently all pregnant women undergo screening for gestational diabetes, a time-consuming and demanding procedure. However, diagnosis often comes late in pregnancy, leaving limited time for intervention. Dr Jonatan Dereke and his fellow researchers at Lund University, Sweden are […]

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Health & Medicine

Therapeutic drug monitoring of methotrexate in disease

Professor Dr Robert de Jonge, Dr Gerrit Jansen, Ittai Muller MSc and Helen Gosselt MSc, Amsterdam University Medical Center, are pioneering analytical approaches which can be used to understand why patients respond differently to the anchor drug used to manage rheumatoid arthritis, called methotrexate. Their work has begun to unravel the key factors behind the mechanism of action of methotrexate, […]

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Health & Medicine

Targeted protein degradation: A new direction for treatment of diseases

Many illnesses are currently treated with drugs that block the action of disease-causing proteins. Often, these drugs work well initially, but over time can become toxic or less effective. A new class of therapeutics called protein degraders, including proteolysis targeting chimeras (‘PROTACs’) and molecular glues shows promise to overcome these challenges. They do so by targeting the disease-causing protein for destruction, […]

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Health & Medicine

Disruptive change in contemporary medical education: Unintended consequences and risks

Undergraduate medical education in the United States is undergoing a process of change in the way teaching is delivered and educational outcomes are assessed. Latterly however there have been questions raised about the pedagogical methods behind the changes, particularly how they affect the teaching of pathology as the basis of medicine, and the development of physician-scientists. Here, we learn more […]

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Health & Medicine

Integrating molecular epidemiology and microbiome science How cancer patients respond to therapy

Understanding the variation in responses to cancer therapeutics would create better treatment for many patients and provide an important basis for further research into new or personalised treatments. It is understood there is a connection between patient response to treatment and their microbiome. However, there is currently a lack of consensus on the microbial signatures present in responsive versus unresponsive […]

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Health & Medicine

The use of fluid mechanics to explore human swimming technique

The use of science to compare swimming mechanisms used by humans and fish may shed light on ways in which human performance can be improved. This underpins the research of Professor Hideki Takagi at the University of Tsukuba, Japan, whose work includes the hydrodynamic and biomechanic study of swimming to explore the impact of competing forces on performance of competitive […]

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Health & Medicine

Shared decision-making in the chronic care of Primary Immunodeficiency

Shared decision-making (SDM) between physicians and patients is vital for the chronic care of conditions such as primary immunodeficiency disorder (PID) as both have to agree on treatments that will continue throughout the patients’ lives. Dr Chris Lamb, CEO and President of BioSolutions Services LLC, examined the effects of SDM on patient participation in treatment decisions. By taking the results […]

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Health & Medicine

Developing a novel inhaled therapeutic for the treatment of bronchiolitis obliterans syndrome

Breath Therapeutics – a Zambon Group Company, is a clinical stage biopharmaceutical company specialising in advanced inhaled therapeutics for severe respiratory diseases. The company’s proprietary liposomal drug formulation has been specifically designed for inhaled administration with an exclusively licensed nebulizer technology. Liposomal cyclosporine A for inhalation (L-CsA-i), an investigational drug, is advancing in phase 3 clinical trials as the first […]

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