Health & Medicine

The genomics of cancer

Many cancers are associated with changes to our genetic material, DNA. These may be small, single unit substitutions, large rearrangements such as deletions or duplications of a part of the DNA sequence, or various other forms of mutations. Although the smaller substitutions have been more intensively studied, Dr Lixing Yang, of the University of Chicago, focuses on uncovering changes at […]

Read More…

Health & Medicine

Reprogramming the immune system for personalised immunotherapy against cancer

For decades, researchers have strived to understand how the immune system recognises and fights cancer, ultimately aiming to exploit and augment these processes to create more effective cancer therapies. Dr Richard Koya, Associate Professor of Oncology, Associate Director of the Center for Immunotherapy, and Director of the Vector Development & Production Facility at Roswell Park Cancer Institute is a prominent […]

Read More…

Health & Medicine

Inhibiting cancer stem cell survival in the hostile tumour environment

Wouldn’t it be great if a small non-toxic molecule could be used to treat cancer? By investigating the possibility of using a cancer cell’s own physiology as a weapon against it, Dr Shoukat Dedhar, at the University of British Columbia, is developing a new treatment that could help prevent tumour growth and metastasis. Every two minutes, someone in the UK […]

Read More…

Health & Medicine

A new class of antibiotic drugs

Finding new classes of antibiotic drugs could not only save human lives, but also greatly reduce the healthcare costs related to tackling bacteria resistant to currently available drugs. Professor Chris McMaster, director of the Cheminformatics Drug Discovery Lab at Dalhousie University in Halifax, Canada, is developing a new class of antibiotics, while trying to overcome the many challenges associated with […]

Read More…

Health & Medicine

Extending the half‑life of therapeutic peptides

Dr Mamoun Alhamadsheh is Associate Professor at the University of the Pacific, Thomas J. Long School of Pharmacy and Health Sciences, California. He heads a multi-disciplinary team working in the field of protein-protein interactions. Their research is focused on the development of new treatments for diseases caused by protein aggregation, including Alzheimer’s disease and transthyretin amyloidosis. Their current work in […]

Read More…

Health & Medicine

Let’s hear it for the proteome

Hearing loss is one of the most common sensory impairments, affecting 250 million people worldwide. The causes of deafness, such as exposure to loud noise, are relatively well known, but exactly how they result in hearing loss remains unclear. Dr Jeffrey Savas, Assistant Professor of Neurology at Northwestern University, Feinberg School of Medicine, USA, heads up a lab dedicated to […]

Read More…

Health & Medicine

Impaired theory of mind associated with very preterm birth – an invisible handicap

Dr Margot Taylor, Director of Functional Neuroimaging at the Hospital for Sick Children and Professor at the University of Toronto, is investigating how very preterm (VPT) birth impacts social cognitive function including Theory of Mind (ToM), a skill that enables us to appreciate that perspectives and beliefs of others can differ from our own. By using neuroimaging techniques, Dr Taylor […]

Read More…

Health & Medicine

Community collaborations targeting breast cancer

Dr Marion Kavanaugh-Lynch directs the California Breast Cancer Research Program of the University of California. Her latest work with the QuickStart programme in California offers coaching for partnership teams formed between communities and academics to conduct participatory research. With a focus on the environmental factors in breast cancer and social disparities in breast cancer, she has forged an important partnership […]

Read More…

Health & Medicine

Raising antibodies against protein complexes

Dr John LaCava of The Rockefeller University has identified a gap in the current availability of target-specific antibodies for the analysis of intracellular protein-protein interactions. Using the latest antibody production techniques, alongside immunoprecipitation and mass spectrometry, he aims to identify important interactions between transcription factors and other macromolecules which are implicated in disease. Proteins are vital for the inner workings […]

Read More…

Health & Medicine

A shining light in the fight against childhood leukaemia?

Dr C. James Lim, PhD, is an Associate Professor at the Department of Pediatrics, University of British Columbia, as well as Investigator at the Michael Cuccione Childhood Cancer Research Program at British Columbia Children’s Hospital, Vancouver, Canada. His research group aims to unravel the mechanisms underlying acquired resistance to chemotherapy in childhood malignancies, with the goal of identifying new treatment […]

Read More…