heart failure Archives

The heart of the matter: Elamipretide in the treatment of Barth syndrome

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Dr Hani Sabbah has spent a decade researching the potential of elamipretide as a therapy for the Barth syndrome.

Barth syndrome (BTHS) is an ultra-rare but debilitating genetic disease affecting cell mitochondria. High infant mortality due to cardiac complications and a weakened immune system significantly decrease life expectancy. Current medications treat symptoms but not the cause, leaving an unmet clinical need to develop effective treatments that target the underlying pathology. Dr Hani N Sabbah, Professor of Medicine at Wayne […]

Moving closer to ideal care for heart failure patients using eHealth and Artificial Intelligence

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DoctorME provides individualised medical advice.

Heart failure (HF) is a growing challenge which imposes unsustainable demands on healthcare systems worldwide. Professor Hans-Peter Brunner-La Rocca and Hesam Amin from Maastricht University Medical Center, are leading the international PASSION-HF project, which is developing an Artificial Intelligence (AI) driven eHealth system that enables self-care for patients with chronic HF. AI, personalised coaching, and serious gaming are included, providing […]

Improving the management of heart failure with telemedicine

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Guaranteeing timely and good quality healthcare for all can be challenging. In countries like Denmark or Brazil, where health administration is fragmented, with federal authorities managing hospitals while municipalities manage primary care, the management of patients is very complicated. After developing a cross-sector collaboration model in Denmark, Dr Helena Dominguez, cardiologist in Bispebjerg-Frederiksberg Hospital and Associate Professor at the University […]

Direct cardiac reprogramming to regenerate the heart

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Infarction causes the loss of a consequent number of cardiac muscle cells. Unable to self-regenerate, these cells are replaced by fibroblasts. This can lead to heart failure. Priyadharshni Muniyandi, doctoral researcher and Dr M. Sheikh Mohamed, Associate Professor at the Bio-Nano Electronics Research Centre, Toyo University, work on direct cardiac reprogramming. Their technique uses microRNA encapsulated in a non-viral nanocarrier: […]

Preventing and treating complications of heart failure and Fabry disease

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Dr Gavin Y Oudit, a distinguished cardiologist from the University of Alberta, focuses his research on developing ground-breaking therapies to treat both genetic and non-genetic cardiovascular disorders, and to prevent heart failure. His exciting work into the role of ACE2 has provided a fundamental scientific understanding used in the development of therapeutic options for cardiovascular, renal and lung diseases. He […]