hypoxia Archives

Genetic evidence implicates respiratory muscle dysfunction in SIDS

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Mr Pontus Sirens highlights genetic evidence about the role that respiratory muscles play in the etiology of SIDS, and highlights the importance to investigate how the diaphragm may impact SIDS

The SIDS-Critical Diaphragm Failure (SIDS-CDF) hypothesis posits that all SIDS risk factors either increase the workload of the diaphragm or reduce its force-generating capacity, and that while SIDS has many contributing factors, it has one cause, namely the failure of the vital respiratory pump. Several SIDS risk factors can impair diaphragm function, but especially noteworthy are the prone sleeping position […]

A new strategy for the treatment of chronic wounds

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A number of people are working in what looks to be a scientific laboratory. Everyone is wearing white coats, and one woman is leaning against a countertop. Dr Manuela Martins-Green investigates the impact of increased OS levels on wound healing by stimulating chronic wound development in a diabetic mouse model.

Wound healing is highly regulated, but oxidative stress (OS) can disturb this healing process in chronic wounds. To better understand the process of initiating chronicity, Dr Manuela Martins-Green and her colleagues at the University of California investigated the impact of increased OS levels on wound healing by stimulating chronic wound development in a diabetic mouse model. The team provides insight […]

Aerosolised medicines may reduce the high risk of coronavirus infection

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Rapid development of vaccines and other preventative measures has been vital in the response to the COVID-19 pandemic. Dr Michael Dubina, full member of the Russian Academy of Sciences, explores a novel method to reduce coronavirus infection risk. His pilot study explored the effects of an aerosolised combination medication in healthcare workers who had not previously been infected with the […]

Guinea pig as a model to study the carotid body-mediated chronic intermittent hypoxia effects

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chronic intermittent hypoxia research outreach

The ability to sense and respond to changes in oxygen is essential for survival. Dr Ángela Gómez-Niño and Dr Asuncion Rocher along with their research team at Valladolid University aim to better understand the physiology and pathophysiology of oxygen sensitivity. In particular, the team employ the use of the guinea pig as a model to explore the mechanisms that mediate […]