The trials and tribulations in the drug discovery cycle: A particular case for Alzheimer’s disease

The trials and tribulations in the drug discovery cycle

As people live longer lives, the spectre of Alzheimer’s disease will only grow. Scientists now know that the amyloid beta (Aβ) peptides are important for treating Alzheimer’s, particularly Aβ42 which aggregates into the amyloid plaques that trigger the disease. Researchers have been looking to target γ-secretase – the enzyme that creates pathogenic Aβ42 affecting the relative abundance of short Aβ […]

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De-icing salt contamination of trees in urban environments

De-icing salt contamination of trees in urban environments

Street trees and other greenery counteract pollution and provide important ecosystem services in urban environments. That this valuable vegetation is under stress has emerged as a research and urbanisation issue. Pierre Vollenweider is based at the Swiss Federal Institute for Forest, Snow and Landscape Research which is concerned with the use, development and protection of natural and urban spaces. Together […]

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Climate change impacts the transmission of vector-borne diseases

Climate change impacts the transmission of vector-borne diseases

Climate change is responsible for changes in temperature and rainfall patterns as well as more frequent extreme events such as floods. These changes may cause insect displacements to regions that are more favourable to them. This can prove to be problematic for local human populations as some of these insects carry diseases: vector-borne diseases are illnesses caused by parasites, viruses […]

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Halalopathy: Integrating mind, behaviour and health

Dr Alzeer believes that the principles of halalopathy will allow the right treatment to be matched to the right patient, allowing for a more effective therapy.

With the current focus on personalised medicine, some physicians are searching for new ways to treat the patient as an individual. Dr Jawad Alzeer of the University of Zurich, Switzerland, proposes a novel approach to medicine: halalopathy. Under halalopathy, mind, behaviour and health are fundamentally connected. By prioritising the relationships between these three aspects of a person, Dr Alzeer believes […]

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The critical gap between management theory and technological reality:
Why many businesses are still failing to innovate effectively

Tschirky proposes his theory of ‘Integrated Technology and Innovation Management’.

Prof Hugo Tschirky is an academic at the Swiss Federal Institute of Technology and specialises in how companies innovate and embrace technology. In 2004, he initiated and co-authored a book called “Bringing technology and innovation into the boardroom” but many of the findings in this book have still yet to be fully embraced by executive boards. Worryingly, a critical gap […]

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Investigating teachers’ psychological and physiological stress

Investigating teachers’ psychological and physiological stress

Professor Dr Alexander Wettstein, Head of the Social Interaction in Educational Settings Research Programme at the University of Teacher Education Bern, is leading an investigation into teachers’ psychobiological stress in social interactions aiming to prevent stress among teachers. His research also examines how aggressive student behaviour and challenging classroom settings can trigger psychological and physiological stress reactions in teachers. The […]

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Agent-based modelling of immigration impact

A multigenerational household of immigrants in Switzerland.

Policy makers depend on immigration policies and quotas, derived from models of the impacts of immigration to design policies that meet the needs of an entire society. Marcello Marini, Dr Ndaona Chokani and Professor Reza S. Abhari from the Laboratory for Energy Conversion (LEC) Group, at ETH Zürich, have developed an artificial intelligence model that significantly reduces simulation times allowing […]

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