cell metabolism Archives

Metabolic dysfunction: The liver and beyond

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Philipp Kaldis and colleagues have conducted extensive research to elucidate the mechanisms of liver diseases, focusing on metabolism and interorgan crosstalk.

The liver is the centre of our metabolism, with metabolic dysfunction playing a pivotal role in liver diseases and type 2 diabetes. Despite extensive study, the mechanisms underlying these pathologies remain largely unexplained. Professor Philipp Kaldis of Lund University, Sweden, has collaborated with fellow researchers to investigate the role of metabolites during metabolic dysfunction in these diseases. Motivated by the goal […]

The adaptive cancer cell: How metastases evolve to resist treatment

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PACCs make up a rare but stable population in standard cell culture.

Species adapt to survive in a changing environment through the process of evolution. Evolutionary processes can also take place at the cellular level. Dr Sarah Amend of Johns Hopkins University, Baltimore, USA, is investigating poly-aneuploid cancer cells (PACCs). These large, DNA-laden cells, which are more common in metastatic cancer, develop evolvability: the capacity to evolve. Dr Amend believes that targeting […]