Improved formulations of nicotinamide riboside: A promising treatment for age-related disorders

an array of samples of nicotinamide riboside

Nicotinamide adenine dinucleotide (NAD+) is a co-enzyme involved in fundamental metabolic roles. Its levels decrease with aging, causing the development of age-related pathologies. NAD+ levels can be replenished by the intake of nicotinamide riboside (NR), a vitamin B3 analogue, which is naturally converted to NAD+. Regular use of NR supplementation is associated with improved outcomes in several cardiovascular, neurodegenerative, and […]

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Novel mouse models shed light on role of omega-6/omega-3 imbalance in chronic disease

Dr Kang's research suggests that a diet high in omega-3 and low in omega-6 helps prevent many chronic diseases.

The link between two classes of essential fatty acids – omega-3 and omega-6 – and health has, until now, been unclear. This is partly because it has been difficult for researchers to define exactly what each does in the body. To address this problem, Dr Jing X. Kang of Massachusetts General Hospital and Harvard Medical School, USA, developed novel strains […]

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Unravelling the secrets of the cell with suspended microchannel resonators

Unravelling the secrets of the cell with suspended microchannel resonators

Researchers can learn much about the properties of many materials simply by weighing them. In cell biology, repeatedly measuring the mass of a cell reveals how fast the cell grows. However, this is very challenging: the mass of a single-cell is extremely difficult to measure with enough accuracy and without perturbing the cell. The laboratory of Dr Scott Manalis at […]

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Using metabolomics and artificial intelligence to explore the universe of the dark metabolome

Using metabolomics and artificial intelligence to explore the universe of the dark metabolome

Professor David Wishart, University of Alberta, is a member of Canada’s national metabolomics laboratory and leads the Human Metabolome Project. His work aims to identify and catalogue metabolites in human tissues, biofluids and the surrounding environment. He has developed a software package called BioTransformer, which is a chemical prediction tool to explore the mysterious dark metabolome. The program combines artificial […]

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