Trifluoromethylpyridine: Its chemistry and applications

Tsukamoto and Nakamura study the chemistry of TFMP derivatives, which are used in the pharmaceutical industry and as chemical feedstock for pest control, fungicidal, and herbicidal agents.

Trifluoromethylpyridine (TFMP) and its intermediates are important ingredients for the development of agrochemical and pharmaceutical compounds. The presence of a fluorine atom and a carbon-containing pyridine are thought to bestow many of the distinctive physical–chemical properties observed with this class of compounds. Dr Masamitsu Tsukamoto and Mr Tadashi Nakamura, of Ishihara Sangyo Kaisha, Ltd, Japan, take a closer look at this […]

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The role of extra chromosomal circular DNA in rapid adaption to glyphosate resistance in pigweed

eccDNAs could constitute the targets of the next generation of herbicides and anti-cancer drugs.

Plants, like other living organisms, have genetic stress-avoidance mechanisms that allow them to become resistant to specific chemicals when continuously exposed to them. Dr Christopher Saski from Clemson University and Dr William Molin from the U.S. Department of Agriculture are researching the extrachromosomal circular DNA (eccDNA) structure known as the replicon of pigweed, which contains the EPSPS gene, the gene […]

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