The role of extra chromosomal circular DNA in rapid adaption to glyphosate resistance in pigweed

eccDNAs could constitute the targets of the next generation of herbicides and anti-cancer drugs.

Plants, like other living organisms, have genetic stress-avoidance mechanisms that allow them to become resistant to specific chemicals when continuously exposed to them. Dr Christopher Saski from Clemson University and Dr William Molin from the U.S. Department of Agriculture are researching the extrachromosomal circular DNA (eccDNA) structure known as the replicon of pigweed, which contains the EPSPS gene, the gene […]

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A new class of antibiotic drugs

a science article about Dr McMaster’s research which focuses on metabolic regulation with an eye toward the development of therapies for unmet medical needs in the infectious and inherited disease spaces.

Finding new classes of antibiotic drugs could not only save human lives, but also greatly reduce the healthcare costs related to tackling bacteria resistant to currently available drugs. Professor Chris McMaster, director of the Cheminformatics Drug Discovery Lab at Dalhousie University in Halifax, Canada, is developing a new class of antibiotics, while trying to overcome the many challenges associated with […]

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