liver Archives

Metabolic dysfunction: The liver and beyond

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Philipp Kaldis and colleagues have conducted extensive research to elucidate the mechanisms of liver diseases, focusing on metabolism and interorgan crosstalk.

The liver is the centre of our metabolism, with metabolic dysfunction playing a pivotal role in liver diseases and type 2 diabetes. Despite extensive study, the mechanisms underlying these pathologies remain largely unexplained. Professor Philipp Kaldis of Lund University, Sweden, has collaborated with fellow researchers to investigate the role of metabolites during metabolic dysfunction in these diseases. Motivated by the goal […]

Shedding light on liver metastasis in pancreatic cancer

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Research into liver metastasis in pancreatic cancer, and how genes can influence tumour growth

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal malignancy, largely as a result of its early spread, or ‘metastasis’, to the liver. Dr Tami Rubinek and Professor Ido Wolf, of the Oncology Division of Tel Aviv Medical Center, Israel, have extensively studied the molecular mechanisms behind liver metastasis in patient tumour samples. They revealed that the absence of certain […]

Unpacking primary biliary cholangitis and its burden in Japan

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Primary biliary cholangitis (PBC) can severely impact a patient's health-related quality of life.

Itch, fatigue, anxiety, abdominal pain. These are just some of the symptoms faced by primary biliary cholangitis (PBC) patients. The chronic autoimmune disease sees white blood cells attack bile ducts in the liver, causing bile overflow, cell damage and potentially scarring and liver failure. Although it can be successfully managed, some symptoms can linger, hampering patients’ health-related quality of life […]