Clostridium difficile infection: Risk factors and potential vaccines

Antibiotics treatment is one of the main factors of risk for developing Clostridium difficile (C. diff) infection, a condition responsible for nearly 500,000 infections and 30,000 deaths each year in the U.S. alone. Dr Joseph Shiloach, Dr Ashish Sharma and their collaborators at the Biotechnology Core Laboratory of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) optimised […]

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Bacterial biofilms: A persisting public health challenge

Bacterial biofilms are a notable public health challenge.

Foodborne and waterborne diseases are major global health threats, exacerbated by the ability of bacteria to gain new characteristics, constantly evolve towards increased fitness in their environment, and by developing resilience through biofilm formation. Utilising emerging technologies such as elevated hydrostatic pressure and application of novel bacteriocin and bactericidal compounds, Professor Aliyar Cyrus Fouladkhah and his team in the Public […]

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Changing climate: A ‘threat multiplier’ for foodborne and waterborne infectious diseases and antibiotic resistance

Aliyar Fouladkhah examines the risks of foodborne pathogens like Listeria monocytogenes.

Dr Aliyar Cyrus Fouladkhah of Tennessee State University is an Assistant Professor in Public Health Microbiology. His laboratory explores preventive measures for the spread of infectious diseases, antibiotic resistance, and food security in the landscape of changing climate. His research aims to provide better understanding of the ecology, epidemiology and effectiveness of control measures of enteric and environmental pathogens at […]

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Unpacking primary biliary cholangitis and its burden in Japan

Primary biliary cholangitis (PBC) can severely impact a patient's health-related quality of life.

Itch, fatigue, anxiety, abdominal pain. These are just some of the symptoms faced by primary biliary cholangitis (PBC) patients. The chronic autoimmune disease sees white blood cells attack bile ducts in the liver, causing bile overflow, cell damage and potentially scarring and liver failure. Although it can be successfully managed, some symptoms can linger, hampering patients’ health-related quality of life […]

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Directed evolution of CRISPR-Cas9 to increase specificity

Directed evolution of CRISPR-Cas9 to increase specificity

Building upon previous CRISPR research and gene editing methods found in nature, Dr Lee and colleagues from ToolGen have developed a method of screening multiple Cas9 variants. Their method seeks to quickly and effectively screen many mutations of Cas9 to find one which possesses maximised on-target activity and minimised off-target activity. After successful development and implementation of the system, Sniper-Screen, […]

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