Tag: neurodegeneration
How oxidative stress contributes to neurodegenerative diseases
The human brain relies on a constant energy supply that when compromised, neurodegenerative disease ensues, initially disrupting nerve cell communication followed by nerve cell death. Paul Hyslop and Michael Chaney investigate fundamental mechanisms driving neurodegenerative disease, to identify therapeutic interventions. They focus on how an enzyme integral to energy supply to nerve cells, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) – is inhibited and […]
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Human Leukocyte Antigens: The missing link in Alzheimer’s disease etiology
Alzheimer’s disease is a huge socioeconomic burden in developed countries. Recently, viral infections such as the herpes virus have been implicated in Alzheimer’s disease risk. However, it is unclear what the link between the two is. Professor Lisa M. James of the University of Minnesota, in collaboration with Dr Apostolos Georgopoulos and Dr Spyros Charonis, has utilised computational biology to […]
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