non-small cell lung cancer Archives

Drug-adapted RET mutations

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The active RET protein has been seen in many types of thyroid cancers.

RET is a protein tyrosine kinase that is upregulated and activated in many diverse forms of cancer. Treatments using RET-specific inhibitors have been highly effective, but the threat of resistance to these drugs looms. For this reason, Dr Jie Wu and Dr Blaine Mooers from the University of Oklahoma, together with Dr Vivek Subbiah from the University of Texas, decided […]

Novel imaging technique could lead to early diagnosis of lung cancer

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Non-small cell lung cancer is one of the most widespread forms of the disease. As with many other cancers, the best chance of survival comes with early diagnosis; unfortunately, at present this often doesn’t happen. In research that has the potential to improve the prognosis of lung cancer patients, Dr Claudio Scafoglio and colleagues at the University of California, Los […]

Understanding the EGFR mutation
aids the fight against lung cancer

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Dr Yamaoka studies the mechanisms of drug resistance in lung cancer patients.

Genetic mutations are known to be responsible for several different types of cancer. One type, known as non-small cell lung cancer, is sometimes caused by mutations in a gene called EGFR. A group of drugs called tyrosine kinase inhibitors are often used to treat patients with this type of cancer. Unfortunately, patients can develop genetic alterations, namely mutation, amplification (an […]