Laboratory lungs: The implications of lung organoids for health and disease

Dr Leibel has developed stem cell-derived lung organoids to learn more about lung development.

Lung disease is a major public health concern. However, research is hindered by the challenges of developing translatable human lung systems in a laboratory setting. Dr Sandra Leibel, neonatologist and Physician Scientist at UCSD and Rady Children’s Hospital in San Diego, USA, is studying lung development and disease mechanisms. In order to do this, she has developed stem cell-derived lung […]

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Transtympanic injections to prevent hearing loss caused by cisplatin

Combination therapies with an otoprotectant may help to prevent hearing loss caused by chemotherapeutic agent cisplatin.

Dr Sofia Waissbluth from The Pontificia Universidad Católica de Chile is specialised in otolaryngology (conditions of the head and neck). She has reviewed clinical trials that use transtympanic injections to prevent hearing loss caused by the chemotherapeutic agent cisplatin. To date there is no ‘one-shot’ solution to protect or cure patients from hearing loss. However, combinational therapy using transtympanic injections […]

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Novel imaging technique could lead to early diagnosis of lung cancer

Novel imaging technique could lead to early diagnosis of lung cancer

Non-small cell lung cancer is one of the most widespread forms of the disease. As with many other cancers, the best chance of survival comes with early diagnosis; unfortunately, at present this often doesn’t happen. In research that has the potential to improve the prognosis of lung cancer patients, Dr Claudio Scafoglio and colleagues at the University of California, Los […]

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Integrating molecular epidemiology and microbiome science
How cancer patients respond to therapy

Integrating molecular epidemiology and microbiome science How cancer patients respond to therapy

Understanding the variation in responses to cancer therapeutics would create better treatment for many patients and provide an important basis for further research into new or personalised treatments. It is understood there is a connection between patient response to treatment and their microbiome. However, there is currently a lack of consensus on the microbial signatures present in responsive versus unresponsive […]

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