How ubiquitin determines the fate of our proteins

How ubiquitin determines the fate of our proteins

Regulation of the multitude of protein-protein interactions that take place in the cell is essential. HECT E3 ubiquitin ligases play an important role in regulating protein functions and maintaining cellular health. However, many questions about their biological functions remain unanswered. Working at the interface of biochemistry and biophysics, Dr Donald Spratt from Clark University in Massachusetts, uses NMR spectroscopy to […]

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Extending the half‑life of therapeutic peptides

This article is about Dr Alhamadsheh’s research which combines synthetic organic chemistry with biochemistry and molecular biology to study protein-protein interactions.

Dr Mamoun Alhamadsheh is Associate Professor at the University of the Pacific, Thomas J. Long School of Pharmacy and Health Sciences, California. He heads a multi-disciplinary team working in the field of protein-protein interactions. Their research is focused on the development of new treatments for diseases caused by protein aggregation, including Alzheimer’s disease and transthyretin amyloidosis. Their current work in […]

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